P Haussermann, S Marczoch, C Klinger, M Landgrebe, B Conrad, A Ceballos-Baumann
Movement Disorders 2004; 19: 303-308

Treatment of cervical dystonia with Dysport remains effective for more than 10 years in approximately 60% of patients, according to this study.
One hundred consecutive patients with CD who received BTX-A injections were followed up after a minimum of 10 and a maximum of 12 years. Six were lost to follow-up and 4 had died. Of the remaining 90, 57 (63%) were still receiving BTX-A injection. For the 32 patients treated continuously in the authors’ clinic, the mean dose per treatment session was 833 U Dysport at a mean of 27 treatment sessions.
Thirty-three patients had ceased treatment, including 3 for secondary nonresponse (with no evidence of antibodies), 11 for side effects, and 12 from the inconvenience of travel for repeat injection. During the follow-up period, 30 of 90 patients developed segmental or multisegmental spread of dystonia, with blepharospasm, oromandibular dystonia, and writer’s cramp the most common forms.

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